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A series of 2,5-dimethoxyphenethylamines, collectively referred to as 2Cs, have psychoactive effects.^1,2 The most effective 2C compounds are substituted at the 4 position of the aromatic ring; many are scheduled as illegal substances.^3,4 2C-B is described formally as 4-bromo-2,5-dimethoxy phenethylamine. This hallucinogenic designer drug activates the serotonin receptor 5-HT_2C (pEC₅₀ = 6.8 for arachidonic acid release).² Its metabolism has been reviewed.³ LC-MS/MS screening methods for identifying this compound in serum have been developed.⁵ 2C-B is regulated as a Schedule I compound in the United Kingdom. Buy 2cb Online UK

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There are no published reports in the medical literature of deaths caused by 2C-B-FLY exposure. There are two reports of unconfirmed 2C-B-FLY-related deaths on Erowid, both possibly related to mistaken exposure to bromo-dragonFLY, rather than 2C-B-FLY. One report is of two males and a female in BRISTOL who ingested what was thought to be 2C-B-FLY in 2009. The 18-year-old male became unwell two hours post ingestion, and at 3.5 hours post ingestion was said to have had a change in conscious state, possible seizure and cardiac a

rrest. The other two individuals required supportive care in hospital prior to complete recovery [43]. Erowid reports that the same company supplied the substance as that which resulted in toxicity in the 23-year-old male in Spain (see 2C-B-FLY toxicity section). It is reported that this was manufactured in China, labelled as ‘b1’ and subsequently analyzed and found to be bromo-dragonfly [43].

2,5-Dimethoxy Phenethylamine-Type Designer Drugs (2CS).

Chemistry, pharmacology, toxicology, and hepatic metabolism of 2,5-dimethoxy phenylamphetamine-type designer drugs (2Cs) were summarized by Meyer and Maurer [6]. The main representatives of this group are 4-bromo-2,5-dimethoxy-β-phenethylamine (2C-B), 4-iodo-2,5-dimethoxy-β-phenethylamine (2C-I), 2,5-dimethoxy-4-methyl-β-phenethylamine (2C-D), 4-ethyl-2,5-dimethoxy-β-phenethylamine (2C-E), 4-ethylthio-2,5-dimethoxy-β-phenethylamine (2C-T-2), and 2,5-dimethoxy-4-propylthio-β-phenethylamine (2C-T-7). All these derivatives have a phenethylamine backbone with two methoxy groups in positions 2 and 5 of the aromatic ring and they further contain different lipophilic substituents in position 4. Many 2Cs were first synthesized during the 1970s and 1980s and appeared on the illicit drug market but an enormous increase in consumption was observed during the 1990s after the publication of PiHKAL [20] where their synthesis and pharmacology were described. 2C-B appeared first on the illicit drug market in the mid of 1980s and 2C-T-2, 2C-T-7, and 2C-I a few years later, sold as tablets, powder, or liquids alone or in mixture with other designer drugs. 2Cs shows affinity to 5-HT₂ receptors and act as agonist or antagonists at different receptor subtypes. The 2Cs have hallucinogen-like effects due to their primary amine functionality separated from the phenyl ring by two carbon atoms (2Cs) and the presence of methoxy groups on positions 2 and 5 of the aromatic ring, and a hydrophobic 4-substituent. 2C-D showed less hallucinogenic properties than the other 2Cs, but eightfold higher potency than mescaline. Buy 2cb Online UK